PokeMe-Dex

Inform your doctor. Protect your health. You are the most important member of your healthcare team — be honest and detailed about everything you're taking or planning to take. Sharing the full picture helps your doctor catch issues early and build a plan that fits your needs.

📋 Comprehensive Metabolic & Hormone Panel: Comprehensive Metabolic Panel (CMP) · Complete Blood Count (CBC) · Lipid Panel (Total Cholesterol, LDL, HDL, Triglycerides, VLDL) · hs-CRP · ESR · TSH · Free T4 · Estradiol (Sensitive) · Total Testosterone · Free Testosterone · SHBG · LH · FSH · Prolactin · DHEA-S · Cortisol (AM) · Vitamin D (25-OH) · Vitamin B12 · Folate · Iron Panel · Ferritin · Magnesium · Zinc · Liver Enzymes (ALT, AST, GGT) · Kidney Function (BUN, Creatinine)
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🦋 Ask Your Doctor to Add — Thyroid Panel: Thyroid issues (hypo/hyperthyroidism) can mimic or worsen symptoms people often blame on peptides — fatigue, weight changes, mood, heart rate. If not already included, ask for: TSH, Free T3, Free T4, and Thyroid Antibodies (TPO/TgAb) if there's a family history of thyroid disease.
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🍬 Ask Your Doctor to Add — Insulin Resistance Panel: Insulin resistance can drive fat gain, cravings, and energy crashes — and is often missed on a standard panel since fasting glucose alone can look "normal." If not already included, ask for: Fasting Insulin, Fasting Glucose, HbA1c (3-month average blood sugar), and HOMA-IR (calculated from fasting glucose + insulin).
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🔥 Ask Your Doctor to Add — Inflammation Panel: Chronic inflammation can affect recovery, gut health, joints, and how well your body responds to peptides. If not already included, ask for: hs-CRP (high-sensitivity C-Reactive Protein), ESR (Erythrocyte Sedimentation Rate), and Homocysteine.
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🟢 Ask Your Doctor to Add — Liver Panel: Many peptides (and underlying issues like fatty liver) are processed through the liver, so a baseline liver panel helps your doctor catch problems early and track changes over time. If not already included, ask for: ALT, AST, ALP (Alkaline Phosphatase), GGT, Total & Direct Bilirubin, Albumin, and Total Protein.
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Even if your doctor disagrees, talk to them anyway. They may catch risks, suggest safer alternatives, or adjust their perspective as new research emerges. Always be honest with your doctor — if they refuse to help or listen, find another. You deserve a doctor who supports you.

Your health. Your responsibility. You decide.

🇺🇸 Thank you to all service men & women — God bless you all.

🌸 PCOS — Vitamins, Supplements & Peptides

💊 SUPPLEMENTS & VITAMINS

Myo-Inositol + D-Chiro Inositol (40:1) — 4g Myo + 400mg D-Chiro daily · restores ovarian function, reduces androgens, improves insulin signaling. 📖 Unfer et al. 2012, Gynecol Endocrinol · Lagana et al. 2019, PMID 31541575

NAC (N-Acetyl Cysteine) — 600mg 3x/day · reduces androgens, improves ovulation rate; shown comparable to Clomiphene in some ovulation-induction trials. 📖 Cheraghi et al. 2020, PMID 32879680 · Nasr 2010, PMID 20035899

Vitamin D3 + K2 — 5,000 IU D3 + 100mcg K2 MK-7 daily · >80% of PCOS women are D-deficient; correcting it improves insulin sensitivity and menstrual regularity. 📖 Wehr et al. 2011, PMID 21934790

Magnesium Glycinate — 300–400mg before bed · reduces cortisol and insulin resistance; hypomagnesemia is more prevalent in PCOS. 📖 Khashchenko et al. 2020, PMID 33088174

Zinc — 30–50mg elemental/day · lowers free androgens (DHT), supports ovulation, reduces hirsutism and acne. 📖 Jamilian et al. 2016, PMID 27164437

Berberine — 500mg 3x/day with meals · activates AMPK (same as Metformin); multiple RCTs show equivalent A1c and insulin reduction in PCOS. 📖 An et al. 2014, PMID 25060831 · Wei et al. 2012, PMID 23134069

Spearmint (Extract or Tea) — 500mg extract or 2 cups tea/day · significant reduction in free testosterone via anti-androgenic activity in RCT. 📖 Grant 2010, PMID 19585478

Omega-3 (EPA + DHA) — 2–4g/day · reduces triglycerides, lowers androgens, reduces liver fat, improves egg quality. 📖 Khani et al. 2017, PMID 28582566

CoQ10 (Ubiquinol) — 200–600mg/day · improves oocyte mitochondrial function and egg quality. 📖 Xu et al. 2018, PMID 30373726

🧬 PEPTIDES FOR PCOS

MOTS-c — 5–10mg 2–3x/week SubQ · activates AMPK in skeletal muscle and liver, directly improving the insulin resistance central to PCOS. 📖 Lee et al. 2015 Cell Metabolism, PMID 25738459

Kisspeptin-10 — 100mcg 2x/week SubQ · regulates GnRH → LH/FSH pulsatility, which is dysregulated in PCOS; clinical trials demonstrate restoration of LH pulsatility. 📖 Skorupskaite et al. 2014, PMID 25368098 · Jayasena et al. 2014, PMID 24463910

BPC-157 — 250–500mcg/day SubQ · reduces systemic inflammation and supports the gut-hormone axis; PCOS involves chronic low-grade inflammation and gut dysbiosis. 📖 Sikiric et al. 2018, PMID 30197782

KPV — 250–500mcg/day SubQ · tripeptide that reduces NF-κB-driven inflammation worsening androgen excess and insulin resistance. 📖 Dalmasso et al. 2008, PMID 18510698

Selank — 250–500mcg/day SubQ or intranasal · reduces cortisol and HPA axis dysregulation, both of which amplify PCOS symptoms. 📖 Semenova et al. 2010, PMID 20803000

SS-31 (Elamipretide) — 1–2mg/day SubQ · improves mitochondrial efficiency and insulin-mediated glucose uptake at the cellular level. 📖 Bhatt et al. 2020, PMID 32217594

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🍬 Insulin Resistance — Vitamins, Supplements & Peptides

💊 SUPPLEMENTS & VITAMINS

Berberine — 500mg 3x/day with meals (1,500mg total) · activates AMPK, inhibits hepatic glucose production; meta-analyses show A1c reduction of 0.5–1.0%. 📖 Yin et al. 2008, PMID 18397984 · Liang et al. 2019 meta-analysis, PMID 31035507

Magnesium Glycinate — 300–400mg/day · cofactor in 300+ insulin-pathway enzymes; RCTs show fasting glucose reduction. 📖 Mooren et al. 2011, PMID 21199787

Alpha-Lipoic Acid (ALA) — 600–1,200mg/day · improves glucose uptake via GLUT4 translocation; used clinically for diabetic neuropathy. 📖 Golbidi et al. 2011, PMID 22123271

Chromium Picolinate — 200–400mcg/day · potentiates insulin receptor tyrosine kinase; RCTs show fasting glucose and HbA1c reductions. 📖 Anderson 1998, PMID 9614170

Vitamin D3 + K2 — 5,000 IU D3 + 100mcg K2 daily · VDR receptors on pancreatic beta cells regulate insulin secretion; D deficiency independently predicts IR. 📖 Nazarian et al. 2011, PMID 21951289

Zinc — 25–30mg elemental/day · required for insulin synthesis, secretion, and crystallization in beta cells. 📖 Jayawardena et al. 2012, PMID 22515411

Ceylon Cinnamon Extract — 1–3g/day · inhibits intestinal glucosidases, improves insulin receptor signaling. Use Ceylon NOT Cassia (coumarin risk). 📖 Khan et al. 2003, PMID 14633804

Omega-3 (EPA + DHA) — 2–4g/day · reduces IRS-1 serine phosphorylation (a key driver of IR), lowers hepatic fat. 📖 Gao et al. 2009, PMID 19561160

CoQ10 (Ubiquinol) — 200–400mg/day · mitochondrial dysfunction is a root cause of IR; CoQ10 improves glucose oxidation. 📖 Mezawa et al. 2012, PMID 22142941

Myo-Inositol + D-Chiro (40:1) — 2g Myo + 200mg D-Chiro daily · inositol serves as a second messenger in insulin signaling; deficiency impairs glucose uptake. 📖 Croze & Soulage 2013, PMID 23764429

🧬 PEPTIDES FOR INSULIN RESISTANCE

MOTS-c — 5–10mg 2–3x/week SubQ · directly activates AMPK in skeletal muscle and liver; demonstrated reversal of high-fat-diet-induced insulin resistance. 📖 Lee et al. 2015 Cell Metabolism, PMID 25738459 · Reynolds et al. 2021, PMID 33753722

SS-31 (Elamipretide) — 1–2mg/day SubQ · improves mitochondrial cristae and electron chain efficiency; IR is fundamentally a mitochondrial disease. 📖 Anderson et al. 2009, PMID 19265020

Semaglutide / Retatrutide / Tirzepatide · gold-standard pharmacological approach; dramatically improves insulin sensitivity, reduces glucagon, lowers fasting glucose. Titrate per standard GLP-1 protocols. 📖 Wilding et al. 2021 NEJM · Jastreboff et al. 2022 NEJM (tirz) · Jastreboff et al. 2023 NEJM (reta)

AOD-9604 — 300–500mcg/day SubQ, fasted · HGH fragment with NO glucose disruption (unlike full HGH); pure lipolysis without worsening IR. 📖 Heffernan et al. 2001, PMID 11522877

BPC-157 — 250–500mcg/day SubQ · reduces cortisol-driven glucose dysregulation and GI inflammation which worsens IR. 📖 Sikiric et al. 2016, PMID 27546276

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🔥 Fat Loss — Vitamins, Supplements & Peptides

💊 SUPPLEMENTS & VITAMINS

L-Carnitine — 1–3g/day · shuttles long-chain fatty acids into mitochondria for beta-oxidation; improves fat utilization during cardio. 📖 Pooyandjoo et al. 2016, PMID 26948242

Green Tea Extract (EGCG) — 400–800mg/day · inhibits COMT, prolonging norepinephrine; shown to increase 24hr EE by 3–4% and fat oxidation by 17%. 📖 Dulloo et al. 1999, PMID 10584049

Vitamin D3 + K2 — 5,000 IU D3 + 100mcg K2 daily · D-deficiency upregulates PTH which triggers fat storage. 📖 Shafinaz & Majid 2015

Electrolytes (Na/K/Mg) — daily — non-negotiable on GLP-1 protocols. Target: 2,000–3,000mg Na, 3,500mg K, 400mg Mg/day.

CoQ10 (Ubiquinol) — 200mg/day · mitochondrial support; maximizes energy from fat oxidation. 📖 Raygan et al. 2016, PMID 27450189

5-HTP — 100–200mg before bed · reduces carbohydrate cravings and appetite on GLP-1 protocols. 📖 Cangiano et al. 1992, PMID 1384305

🧬 PEPTIDES FOR FAT LOSS

Retatrutide — 2–12mg once/week SubQ (titrate slowly) · triple agonist (GLP-1/GIP/Glucagon); 24.2% weight loss at 48 weeks in Phase 2. 📖 Jastreboff et al. 2023 NEJM, PMID 37351564

Tirzepatide — 2.5–15mg once/week SubQ · dual GLP-1/GIP; 22.5% average body weight loss at 72 weeks in SURMOUNT-1. 📖 Jastreboff et al. 2022 NEJM, PMID 35658024

Semaglutide — 0.25–2.4mg once/week SubQ · GLP-1 agonist; 14.9% average body weight loss in STEP-1 trial. 📖 Wilding et al. 2021 NEJM, PMID 33567185

AOD-9604 — 300–500mcg/day SubQ, fasted · pure lipolysis from HGH C-terminal fragment; no IGF-1 activation, no glucose disruption. 📖 Heffernan et al. 2001, PMID 11522877

Tesamorelin — 1–2mg/day SubQ · FDA-approved GHRH analog for visceral fat reduction; reduces visceral adipose by 15–20%. 📖 Falutz et al. 2010, PMID 20173752

MOTS-c — 5–10mg 2–3x/week SubQ · improves fat metabolism and exercise efficiency via AMPK. 📖 Lee et al. 2015, PMID 25738459

5-Amino-1MQ — 50mg/day oral · NNMT inhibitor; reduces fat mass while preserving lean mass by upregulating NAD+ metabolism. 📖 Neelakantan et al. 2019, PMID 31241378

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💪 Muscle & Recovery — Vitamins, Supplements & Peptides

💊 SUPPLEMENTS & VITAMINS

Creatine Monohydrate — 5g/day · most-researched supplement; increases phosphocreatine stores, improves strength by 5–15%, accelerates recovery. 📖 Lanhers et al. 2017 meta-analysis, PMID 27328852

Magnesium Glycinate — 400mg/day · reduces DOMS, improves sleep depth, prevents neuromuscular cramping. 📖 Setaro et al. 2014, PMID 23675073

Zinc — 25–30mg/day · required for testosterone synthesis, protein metabolism, immune recovery post-training. 📖 Prasad et al. 1996, PMID 8875519

Vitamin D3 + K2 — 5,000 IU D3 + 100mcg K2 daily · D3 upregulates IGF-1 and muscle protein synthesis. 📖 Close et al. 2013, PMID 23860653

Omega-3 (EPA + DHA) — 3–4g/day · activates mTOR, reduces DOMS, shown to increase muscle protein synthesis by 50% in older adults. 📖 Smith et al. 2011, PMID 21159787

HMB (Beta-Hydroxy-Beta-Methylbutyrate) — 3g/day · leucine metabolite; reduces muscle protein breakdown, improves net protein balance. 📖 Wilson et al. 2014, PMID 25028999

🧬 PEPTIDES FOR MUSCLE & RECOVERY

BPC-157 — 250–500mcg/day SubQ · accelerates tendon-to-bone healing, reduces inflammation, upregulates GH receptors. 📖 Chang et al. 1997, PMID 9234028 · Sikiric et al. 2018, PMID 30197782

TB-500 (Thymosin Beta-4) — 2–2.5mg 2x/week SubQ x4–6 wks, then 2mg monthly · promotes actin cell motility, angiogenesis, and tissue remodeling. 📖 Goldstein & Kleinman 2015, PMID 25754600

CJC-1295 No-DAC + Ipamorelin — 200–300mcg each at bedtime 5x/week · pulsatile GH release during deep sleep for recovery and body recomposition. 📖 Teichman et al. 2006 PMID 16945971 · Raun et al. 1998 PMID 9849822

GHK-Cu — 1–2mg/day SubQ · stimulates collagen and elastin synthesis, promotes nerve regeneration, upregulates anti-inflammatory genes. 📖 Pickart et al. 2018, PMID 30469512

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🧬 Anti-Aging & Longevity — Vitamins, Supplements & Peptides

💊 SUPPLEMENTS & VITAMINS

NMN (Nicotinamide Mononucleotide) — 500mg–1g/day morning · NAD+ declines 50% from age 20→50; restores sirtuin activity, DNA repair, and mitochondrial function. 📖 Yoshino et al. 2021 Science, PMID 34582786 · Mills et al. 2016 Cell Metabolism, PMID 27411018

CoQ10 (Ubiquinol form) — 200–400mg/day with fat · critical for mitochondrial ATP production and antioxidant defense; declines with age and statin use. 📖 Mantle et al. 2018, PMID 29397563

Resveratrol — 500mg/day with fat · SIRT1 activator; synergistic with NMN for NAD+ pathway activation. 📖 Lagouge et al. 2006 Cell, PMID 17112576

Magnesium L-Threonate — 2g/day · only form shown to cross the blood-brain barrier; improves synaptic density and cognitive aging. 📖 Liu et al. 2016, PMID 27021134

Vitamin D3 + K2 — 5,000 IU D3 + 100mcg K2 MK-7 · D3 activates 200+ longevity-related genes; K2 prevents arterial calcification. 📖 Schurgers et al. 2007, PMID 17002740

Omega-3 (EPA + DHA) — 2–4g/day · reduces telomere shortening rate; lowers IL-6 and TNF-α. 📖 Farzaneh-Far et al. 2010 JAMA, PMID 20085953

🧬 PEPTIDES FOR ANTI-AGING

Epithalon — 10mg/day SubQ x10–20 days, 1–2x/year · induces telomerase, elongates telomeres, restores pineal melatonin secretion. 📖 Khavinson et al. 2003, PMID 14523360 · Anisimov et al. 2003, PMID 14533127

GHK-Cu — 1–2mg/day SubQ · resets gene expression toward a younger state; downregulates 30+ inflammation genes, upregulates repair genes. 📖 Pickart & Margolina 2018, PMID 30469512

NAD+ (SubQ) — 50–500mg SubQ 3–5x/week · direct NAD+ repletion; bypasses conversion step vs NMN/NR. 📖 Rajman et al. 2018 Cell Metabolism, PMID 29514063

MOTS-c — 5–10mg 2–3x/week SubQ · restores mitochondrial homeostasis; shown to increase lifespan in mouse models. 📖 Lee et al. 2015, PMID 25738459

Thymalin — 5–10mg SubQ x10 days, 2x/year · thymic bioregulator; shown in 35-year Russian longevity study to reduce mortality by 2.5×. 📖 Khavinson & Morozov 2003, PMID 14523378

Thymosin Alpha-1 — 1.6mg 2x/week SubQ · boosts T-cell maturation and dendritic cell function; FDA-approved in some countries. 📖 Garaci et al. 2012, PMID 22325148

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🧠 Cognitive & Focus — Vitamins, Supplements & Peptides

💊 SUPPLEMENTS & VITAMINS

Lion's Mane (fruiting body) — 1–3g/day · stimulates NGF and BDNF production; RCT showed improved cognitive scores over 16 weeks. 📖 Mori et al. 2009, PMID 18844328

Omega-3 DHA — 1–2g DHA/day · DHA is ~40% of brain PUFAs; low DHA is independently associated with cognitive decline. 📖 Denis et al. 2013, PMID 23232018

Magnesium L-Threonate — 2g/day · improves working memory and long-term memory consolidation by increasing hippocampal synaptic density. 📖 Liu et al. 2016, PMID 27021134

Bacopa Monnieri (50% bacosides) — 300–600mg/day · improves information retention and processing speed; effects take 8–12 weeks. 📖 Stough et al. 2001, PMID 11498727

B-Complex + Methylfolate + B12 — daily · homocysteine reduction, myelin synthesis, neurotransmitter production. 📖 Kennedy 2016, PMID 28176720

L-Theanine + Caffeine (2:1) — 200mg theanine + 100mg caffeine · alpha-wave generator; improves sustained attention and reduces jitteriness. 📖 Owen et al. 2008, PMID 18681988

🧬 PEPTIDES FOR COGNITIVE FUNCTION

Semax — 300–600mcg/day intranasal (or 200–500mcg SubQ) · ACTH analog; upregulates BDNF, improves focus and memory encoding within days. 📖 Dolotov et al. 2006, PMID 16765471

Selank — 250–500mcg/day intranasal · anxiolytic nootropic; modulates GABA-A and serotonin without sedation. 📖 Semenova et al. 2010, PMID 20803000

Dihexa (PNB-0408) — 10–30mg oral or topical · potent BDNF-mimetic; estimated 7 orders of magnitude more potent than BDNF. Start very low. 📖 McCoy et al. 2013, PMID 23462217

NAD+ / NMN — SubQ or oral · cerebral NAD+ depletion is a hallmark of neurodegeneration; repletion restores neuronal energy and DNA repair. 📖 Hou et al. 2021, PMID 33499922

Pinealon — 1–2mg/day SubQ x10 days · brain bioregulator; restores sleep-wake cycles which directly impact memory consolidation. 📖 Khavinson 2002 (Bioregulatory peptides series)

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😴 Sleep — Vitamins, Supplements & Peptides

💊 SUPPLEMENTS & VITAMINS

Magnesium Glycinate — 400mg 30–60 min before bed · calms NMDA receptors, reduces cortisol, activates parasympathetic nervous system. 📖 Abbasi et al. 2012, PMID 23853635

L-Theanine — 200–400mg before bed · increases alpha brain waves, reduces excitatory glutamate; no grogginess. 📖 Nobre et al. 2008, PMID 18296328

Ashwagandha (KSM-66) — 300–600mg at night · lowers cortisol by 28% in RCTs; improves sleep quality and morning alertness. 📖 Langade et al. 2019, PMID 31728244

Melatonin — 0.5–1mg (LOW DOSE) 30 min before bed · ⚠ physiological dose is 0.1–0.3mg; doses above 1mg cause grogginess and receptor desensitization. DO NOT take 5–10mg. 📖 Brzezinski et al. 2005, PMID 15649737

Glycine — 3g before bed · lowers core body temperature (required for sleep onset), improves sleep depth in RCTs. 📖 Bannai et al. 2012, PMID 22293292

Apigenin — 50mg before bed · chamomile-derived; binds GABA-A for mild sedation without tolerance. 📖 Viola et al. 1995, PMID 7491282

🧬 PEPTIDES FOR SLEEP

CJC-1295 No-DAC + Ipamorelin — 200–300mcg each at bedtime 5x/week · amplifies the natural nocturnal GH pulse critical for recovery. 📖 Teichman et al. 2006, PMID 16945971

DSIP (Delta Sleep-Inducing Peptide) — 100–300mcg SubQ 30–60 min before bed · promotes delta-wave (deep) sleep; normalizes cortisol patterns. 📖 Khvatova et al. 2003, PMID 14638183

Epithalon — 5–10mg/day SubQ x10 days · restores pineal melatonin production that declines with age; normalizes circadian rhythm at the source. 📖 Khavinson & Morozov 2003, PMID 14523378

Selank — 250–500mcg intranasal before bed · reduces evening anxiety and racing thoughts without sedation hangover. 📖 Semenova et al. 2010, PMID 20803000

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🌀 Gut Health — Vitamins, Supplements & Peptides

💊 SUPPLEMENTS & VITAMINS

L-Glutamine — 5–10g/day split doses · primary fuel for enterocytes; repairs leaky gut and maintains villous architecture. 📖 Kim & Kim 2017, PMID 28990538

Probiotics (multi-strain) — 10–50 billion CFU/day · restores microbiome diversity; reduces SIBO relapse, improves IBS. 📖 Ford et al. 2014 meta-analysis, PMID 24853034

Zinc Carnosine (PepZin GI) — 75mg 2x/day on empty stomach · specifically repairs gastric/intestinal mucosa; reduces zonulin (leaky gut marker). 📖 Mahmood et al. 2007, PMID 17435416

Collagen Peptides — 10–20g/day · provides glycine and proline for intestinal collagen matrix. 📖 Chen et al. 2017, PMID 29439148

Butyrate (Sodium/Calcium) — 300–600mg/day · primary colonocyte fuel; activates Treg cells, reduces intestinal inflammation. 📖 Canani et al. 2011, PMID 21224837

DGL (Deglycyrrhizinated Licorice) — 400–800mg before meals · promotes mucin secretion and prostaglandin synthesis in gastric mucosa. 📖 Dehpour et al. 1994, PMID 7978533

🧬 PEPTIDES FOR GUT HEALTH

BPC-157 — 250–500mcg/day SubQ (or oral for gut-specific) · most-studied gut-healing peptide; repairs ulcers, IBS, IBD, fistulas. 📖 Sikiric et al. 2016, PMID 27546276 · Klicek et al. 2013, PMID 23475785

KPV — 250–500mcg/day SubQ or oral · directly inhibits NF-κB in intestinal epithelial cells; clinically relevant for IBD and colitis. 📖 Dalmasso et al. 2008, PMID 18510698

Larazotide Acetate — 0.5–1mg/day oral · tight junction regulator (zonulin antagonist); seals leaky gut at the molecular level; Phase 2/3 trials for celiac and long-COVID. 📖 Leffler et al. 2015, PMID 25671487 · Murray et al. 2011, PMID 21224033

VIP (Vasoactive Intestinal Peptide) — 50–100mcg SubQ 2–3x/week · reduces gut inflammation, promotes mucosal healing, regulates intestinal motility. 📖 Lodolce et al. 2000, PMID 10837484

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🦴 Autoimmune & Rheumatic Disease (RA · Lupus · Psoriasis · IBD · Polymyalgia · Sjögren's) — Vitamins, Supplements & Peptides

💊 SUPPLEMENTS & VITAMINS

Omega-3 (EPA + DHA) — 3–4g/day · suppresses leukotriene B4 and PGE2; multiple RCTs show reduction in morning stiffness and joint pain in RA. 📖 Proudman et al. 2015, PMID 25320462 · Calder 2015, PMID 25800563

Vitamin D3 + K2 — 5,000–10,000 IU D3 + 100mcg K2 daily · VDR activation on T-cells and macrophages directly modulates immune activity; D deficiency is near-universal in autoimmune disease and independently predicts flares. 📖 Correale et al. 2009, PMID 19604026 · Cantorna 2010, PMID 20966408

Magnesium Glycinate — 400–600mg/day · cofactor in 300+ enzymatic reactions; magnesium deficiency amplifies NF-κB signaling and cytokine release. 📖 Mazur et al. 2007, PMID 17675186

Curcumin (with Piperine) — 500–1,000mg 2x/day · inhibits NF-κB and COX-2; RCTs show equivalent NSAID efficacy for joint pain in RA with superior GI tolerability. 📖 Chandran & Goel 2012, PMID 22407780 · Daily et al. 2016, PMID 27213821

Boswellia Serrata (AKBA) — 100–200mg AKBA/day · inhibits 5-LOX (the leukotriene pathway), reducing joint inflammation without NSAID side effects. 📖 Sengupta et al. 2010, PMID 20359267

NAC (N-Acetyl Cysteine) — 600mg 2–3x/day · precursor to glutathione; reduces oxidative stress that drives autoimmune tissue damage and cytokine storm. 📖 Lai et al. 2010, PMID 20048489

Quercetin — 500–1,000mg/day · inhibits histamine release and pro-inflammatory cytokine production; stabilizes mast cells relevant to lupus and Sjögren's. 📖 Li et al. 2016, PMID 26616308

Zinc — 25–30mg elemental/day · required for regulatory T-cell function and thymulin production; deficiency worsens autoimmune activity. 📖 Haase & Rink 2009, PMID 19371543

Probiotics (multi-strain) — 50B+ CFU/day · gut dysbiosis is a root driver of autoimmune disease; Lactobacillus and Bifidobacterium strains reduce Th17/Treg imbalance central to RA, IBD, and psoriasis. 📖 Zamani et al. 2016, PMID 27370920

Low-Dose Naltrexone (LDN) — 1.5–4.5mg/night · modulates TLR4 signaling and microglial activation; used off-label for RA, Crohn's, MS, psoriasis with growing evidence base. 📖 Younger & Mackey 2009, PMID 19265012 · Cree et al. 2010, PMID 20085681

🧬 PEPTIDES FOR AUTOIMMUNE & RHEUMATIC DISEASE

BPC-157 — 250–500mcg/day SubQ or oral · upregulates NO-cGMP signaling which reduces systemic immune overactivation; heals gut lining (a root trigger of autoimmune disease via leaky gut → molecular mimicry). 📖 Sikiric et al. 2018, PMID 30197782

TB-500 — 2–5mg 2x/week SubQ (loading), then 2mg/week · reduces TNF-α in inflamed connective tissue; promotes repair of cartilage, synovium, and tendons damaged by chronic inflammation in RA and psoriatic arthritis. 📖 Goldstein et al. 2012, PMID 22226572

KPV — 250–500mcg/day SubQ or oral · a direct NF-κB inhibitor via the melanocortin-1 receptor; suppresses the master inflammatory switch driving IBD, RA, and psoriasis at the cellular level. 📖 Dalmasso et al. 2008, PMID 18510698 · Kannengiesser et al. 2008

VIP (Vasoactive Intestinal Peptide) — 50–100mcg SubQ 2–3x/week · one of the most potent endogenous anti-inflammatory neuropeptides; directly suppresses TNF-α, IL-6, IL-12 in macrophages and T-cells. Studied in RA, IBD, and lupus clinical models. 📖 Delgado et al. 2004, PMID 14978027 · Abad et al. 2010, PMID 20498071

Thymosin Alpha-1 (TA-1) — 1.6mg SubQ 2x/week · restores Treg/Th17 balance — regulatory T-cell deficiency allows autoimmune overactivation to persist; TA-1 directly corrects this imbalance. Used clinically for autoimmune hepatitis and lupus in some countries. 📖 Tuthill et al. 2006, PMID 16336577 · Camerini et al. 2000

GHK-Cu — 1–2mg/day SubQ · reduces IL-6 and TNF-α while stimulating collagen synthesis — targets both the inflammatory cytokine cascade and the connective tissue destruction central to RA, psoriasis, and Sjögren's. 📖 Pickart et al. 2015, PMID 26060882

Selank — 250–500mcg/day SubQ or intranasal · modulates HPA axis and reduces stress-induced immune dysregulation; chronic HPA activation worsens autoimmune flares through cortisol-driven cytokine imbalance. 📖 Semenova et al. 2010, PMID 20803000

SS-31 (Elamipretide) — 1–2mg/day SubQ · improves mitochondrial function and reduces ROS — mitochondrial dysfunction and oxidative stress are primary amplifiers of chronic autoimmune inflammation and fatigue. 📖 Szeto 2014, PMID 25251836

MOTS-c — 5–10mg 2–3x/week SubQ · activates AMPK which directly suppresses NF-κB and reduces pro-inflammatory cytokine output; studied for systemic anti-inflammatory and metabolic effects in immune-driven conditions. 📖 Lee et al. 2015, PMID 25738459

LL-37 — 0.5–1mg SubQ 2–3x/week · modulates innate immune signaling; reduces pathological TLR activation that drives psoriasis, IBD, and lupus while preserving antimicrobial defense. 📖 Kahlenberg & Kaplan 2013, PMID 23702143

Thymulin — 0.05–0.1mg SubQ 2–3x/week · thymus hormone that regulates T-cell maturation; zinc-dependent — supplement zinc alongside it. Corrects the T-regulatory deficits that allow autoimmune overactivation. 📖 Dardenne 2002, PMID 11812338

⚠ GLP-1 NOTE: Semaglutide, Tirzepatide, and Retatrutide suppress the same cytokines (TNF-α, IL-6, IL-17) targeted by expensive biologic drugs. If you are on a GLP-1 for weight loss AND have an autoimmune condition, discuss the immune implications with your rheumatologist — you may already be getting meaningful anti-inflammatory benefit.

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